The "Merc with a Mouth" is back in "Deadpool & Wolverine," set to debut with $160 million to $180 million at the domestic box office. This film is already the top ticket preseller of 2024 and has broken the records for the highest domestic opening of the year and the biggest debut for an R-rated film.

Currently, "Inside Out 2" holds the highest opener of 2024 with $154.2 million, while the first "Deadpool" holds the R-rated record with $132.4 million.

This film is the 34th MCU release and the first R-rated under Disney after acquiring 20th Century Fox.

With limited press screenings and strong fan anticipation, audiences are eager to avoid spoilers. Analysts expect repeated viewings due to the film's humor and Easter eggs, along with strong sales from premium screenings and licensed merchandise.

"Deadpool & Wolverine" is critical for the MCU as Disney focuses on quality amid a crowded market. The chemistry between Ryan Reynolds and Hugh Jackman enhances interest, with audiences curious about how the film will maintain the qualities of previous R-rated hits.